![]() Δ 9-Tetrahydrocannabinol (THC), the primary psychoactive constituent of Cannabis sativa/indica, produces its characteristic cannabinoid effects through activation of the endocannabinoid system, one of several lipid signaling systems in the brain. Further, animal models using translationally relevant ROA may facilitate more accurate predictions of their effects in humans. The results of this examination of the effects of ROA on an abuse-related effect of THC provide an empirical foundation to facilitate choice of ROA for mechanistic investigation of THC’s pharmacology. During the time course analysis, aerosol administration had the shortest latency to onset of discriminative stimulus effects and the shortest duration of effect, whereas s.c. and p.o.), THC potency was lower with s.c. While potencies were similar for ROA involving first-pass metabolism (i.p. THC fully substituted for the 3 mg/kg i.p. ![]() Both sexes acquired THC discrimination in a similar number of sessions, although baseline response rates were significantly lower in females than males. Following acquisition, dose-effect curves were determined with THC using i.p., oral (p.o.), and subcutaneous (s.c.) injection in both sexes and aerosol exposure in males only, followed by a time course with one dose for each ROA. Adult female and male Long Evans rats were trained to discriminate intraperitoneal (i.p.) THC from vehicle in a drug discrimination procedure. The present study examined the effects of route of administration (ROA) of Δ 9-tetrahydrocannabinol (THC), the primary psychoactive constituent of cannabis. Cannabis users typically smoke or vape cannabis or ingest it in edibles, whereas cannabinoids are typically administered via injection in rodent research.
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